Poster, SOT 63rd Annual Meeting and ToxExpo, March 10–14, 2024, Salt Lake City, Utah.
Sabina Burla1,2, Aline Chary1, Pamina Weber1, Tommaso Serchi1, Arno C. Gutleb1,2
1 Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg;
2 invitrolize sarl, Belvaux, Luxembourg; a Current affiliation: invitrolize sarl, Belvaux, Luxembourg;
The objective of the study was to evaluate the responsiveness of an in vitro test system designed for the prediction of chemical respiratory sensitizers – ALIsens® (Figure 3f) (Chary et al., 2019). The cellular arrangement enables the development of a tissue microenvironment (Figure 1) achieved by direct communication between cells (Figure 2) and indirectly via secreted messenger molecules. Additionally, it facilitates the exposure to respiratory sensitizers in a realistic approach, at the air-liquid-interface (ALI), as well as in submerged conditions.
