News & Publications

February 11, 2024

Quantitative Modeling of In Vitro Data Using an Adverse Outcome Pathway for the Risk Assessment of Decreased Lung Function in Humans

https://doi.org/10.1016/j.toxlet.2024.02.001 Alain Sewer, Marja Talikka , Florian Calvino-Martin, Karsta Luettich, Anita IskandarPMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland Highlights […]

February 9, 2024

A Novel Bionebulizer Approach to Study the Effects of Natural Mineral Water on a 3D In Vitro Nasal Model from Allergic Rhinitis Patients

https://doi.org/10.3390/biomedicines12020408 Joana Viegas 1, Elsa M. Cardoso 1,2, Lucile Bonneau 1, Ana Filipa Esteves 1, Catarina L. Ferreira 1,3, Gilberto […]

February 5, 2024

In vitro neurotoxicity of particles from diesel and biodiesel fueled engines following direct and simulated inhalation exposure

https://doi.org/10.1016/j.envint.2024.108481 Lora-Sophie Gerber a b, Dirk C.A. de Leijer a, Andrea Rujas Arranz a, Jonas M.M.L. Lehmann a b, Meike […]

February 2, 2024

Air/Liquid Interface Special Session at European Aerosol Conference 2024

August 25th–30th in Tampere, Finland. An excellent opportunity to discuss ALI exposures. Session title: “Toxicity of Aerosols: Exploring Air-Liquid Interface […]

January 20, 2024

Acute exposure to seasonal PM2.5 induces toxicological responses in A549 cells cultured at the air-liquid interface mediated by oxidative stress and endoplasmic reticulum stress

DOI: 10.1016/j.envres.2024.118283 Wankang Chen 1, Pengxiang Ge 1, Zhenyu Lu 1, Xiaoming Liu 1, Maoyu Cao 2, Zhansheng Yan 1, […]

January 19, 2024

Did you know why we use stainless steel for our exposure systems as much as we can?

Medical grade stainless steel, particularly “V4A”, is our preferred material choice for in vitro exposure systems. It is inert, exhibits […]

January 18, 2024

Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers

https://doi.org/10.3390/ijms24031927 Alexandra Friesen 1, Susanne Fritsch-Decker 2, Sonja Mülhopt 3, Caroline Quarz 1, Jonathan Mahl 3, Werner Baumann 3, Manuela […]

January 15, 2024

Product News 01/2024

See our new VITROCELL® 12/12 PLUS for 12- or 24-well sized inserts. This Exposure System has been specifically designed and […]

December 30, 2023

The use of a complex tetra-culture alveolar model to study the biological effects induced by gold nanoparticles with different physicochemical properties

https://doi.org/10.1016/j.etap.2023.104353 Melissa Saibene a b, Tommaso Serchi a, Patrizia Bonfanti b, Anita Colombo b, Inge Nelissen c, Rashi Halder e, […]

December 26, 2023

Ultrafine Particles Issued from Gasoline-Fuels and Biofuel Surrogates Combustion: A Comparative Study of the Physicochemical and In Vitro Toxicological Effects

https://doi.org/10.3390/toxics11010021 Ana Teresa Juárez-Facio 1, Tiphaine Rogez-Florent 1, Clémence Méausoone 1, Clément Castilla 2, Mélanie Mignot 2, Christine Devouge-Boyer 2, […]

December 25, 2023

The Cytotoxic Effects of Fine Particulate Matter (PM2.5) from Different Sources at the Air-Liquid Interface Exposure on A549 Cells

DOI: 10.3390/toxics12010021 Zhansheng Yan 1, Pengxiang Ge 1, Zhenyu Lu 1, Xiaoming Liu 1, Maoyu Cao 2, Wankang Chen 1, […]

December 21, 2023

VITROCELL at the Workshop “Aerosol and Health” of The Hong Kong Polytechnic University, Universität Rostock and Helmholtz Munich on 06 December 2023 in Rostock

++++++++++ REVIEW: The one day meeting summarized the current work by the research groups of and The latest technologies in […]

December 21, 2023

VITROCELL at LIVe2024 – 20-21. June 2024

++++++++ REVIEW: LIVe 2024 in Nice/France was very lively It was great to meet so many VITROCELL users and interested […]

December 21, 2023

2024 User Group Meeting

We wish to invite you to participate in our User Group Meeting 2024, an excellent opportunity to discuss our latest […]

December 15, 2023

Validation of the VITROCELL Mammalian 48 Exposure Module Using In Vitro Cytotoxicity via the Neutral Red Uptake Assay in Chinese Hamster Ovary Cells Following Exposure to Whole Smoke from Combustible Cigarettes

https://doi.org/10.1089/aivt.2023.0013 Brian M. Keyser1, Robert Leverette1, Michael Hollings2, Emma Rothwell2, Randy A. Weidman1, Carlton J. Bequette1, and Kristen Jordan11Scientiﬁc & […]

November 10, 2023

In vitro lung cell exposure at the air-liquid interface shows significant increase in publications.

Indicating a shift from animal testing towards alternative methods. Sonja Mülhopt from our cooperation partner, the Karlsruhe Institute of Technology […]

October 29, 2023

Inhalation toxicity of thermal transformation products formed from e-cigarette vehicle liquid using an in vitro lung model exposed at the Air–Liquid Interface

https://doi.org/10.1016/j.fct.2023.114157 T. Ruth a, J. Daniel b, A. Konig a, R. Trittler c, M. Garcia-Kaufer aa Institute for Infection Prevention […]

October 20, 2023

Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model

https://doi.org/10.1186/s12989-023-00550-w Gerrit Bredeck1, Jochen Dobner1, Burkhard Stahlmecke2, Khanneh Wadinga Fomba3, Hartmut Herrmann3, Andrea Rossi1 and Roel P. F. Schins11IUF – […]

October 10, 2023

Impact of Electronic Cigarettes, Heated Tobacco Products and Conventional Cigarettes on the Generation of Oxidative Stress and Genetic and Epigenetic Lesions in Human Bronchial Epithelial BEAS-2B Cells

https://doi.org/10.3390/toxics11100847 Gianni Zarcone , Marie Lenski , Thomas Martinez, Smaïl Talahari, Ophélie Simonin, Guillaume Garçon, Delphine Allorge, Fabrice Nesslany, Jean-Marc […]

October 8, 2023

In vitro micronucleus in V79 cells using MicroFlow® – Treatment at the air liquid interface with aerosol from three different nicotine containing products

CORESTA SSPT, October 8-12, 2023, Cancun, Mexico Emma Rothwell, Gina Smith, Sophie Martin and Michael Hollings;Labcorp Early Development Laboratories Ltd., […]

October 8, 2023

In vitro cytotoxicity and mechanistic insight from MucilAir™ and SmallAir™ tissues exposed to cigarette smoke and next-generation products

CORESTA SSPT, October 8-12, 2023, Cancun, Mexico Hollings, M1; Rothwell E1; Martin S1; Daunt, A1; Freiberg, G2; Bedford, R1;Labcorp Early […]

October 8, 2023

Validation of the Vitrocell® HTP 2.0+ 12-well mammalian module for assessing cigarettes, ENDS and eHTPs: Evaluation of dilution airflow, dose resolution and dose repeatability

CORESTA SSPT, October 8-12, 2023, Cancun, Mexico Adam Seymour, Emma Rothwell, Sophie Martin and Michael Hollings;Labcorp Early Development Laboratories Ltd., […]

September 28, 2023

A multi-organ, lung-derived inflammatory response following in vitro airway exposure to cigarette smoke and next-generation nicotine delivery products

https://doi.org/10.1016/j.toxlet.2023.09.010 R. Bedford a, G. Smith a, E. Rothwell a, S. Martin a, R. Medhane a, D. Casentieri a, A. […]

September 25, 2023

VITROCELL at the CORESTA Conference of the Smoke Science and Product Technology Sub-Groups (SSPT2023), 08-12 October 2023

++++++++++ REVIEW: Sunrise for NAMs NAMs (New Approach Methods) are in vitro and in silico or computational-based methodologies in toxicology […]

News & Publications

Quantitative Modeling of In Vitro Data Using an Adverse Outcome Pathway for the Risk Assessment of Decreased Lung Function in Humans

A Novel Bionebulizer Approach to Study the Effects of Natural Mineral Water on a 3D In Vitro Nasal Model from Allergic Rhinitis Patients

In vitro neurotoxicity of particles from diesel and biodiesel fueled engines following direct and simulated inhalation exposure

Air/Liquid Interface Special Session at European Aerosol Conference 2024

Acute exposure to seasonal PM2.5 induces toxicological responses in A549 cells cultured at the air-liquid interface mediated by oxidative stress and endoplasmic reticulum stress

Did you know why we use stainless steel for our exposure systems as much as we can?

Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers

Product News 01/2024

The use of a complex tetra-culture alveolar model to study the biological effects induced by gold nanoparticles with different physicochemical properties

Ultrafine Particles Issued from Gasoline-Fuels and Biofuel Surrogates Combustion: A Comparative Study of the Physicochemical and In Vitro Toxicological Effects

The Cytotoxic Effects of Fine Particulate Matter (PM2.5) from Different Sources at the Air-Liquid Interface Exposure on A549 Cells

VITROCELL at the Workshop “Aerosol and Health” of The Hong Kong Polytechnic University, Universität Rostock and Helmholtz Munich on 06 December 2023 in Rostock

VITROCELL at LIVe2024 – 20-21. June 2024

2024 User Group Meeting

Validation of the VITROCELL Mammalian 48 Exposure Module Using In Vitro Cytotoxicity via the Neutral Red Uptake Assay in Chinese Hamster Ovary Cells Following Exposure to Whole Smoke from Combustible Cigarettes

In vitro lung cell exposure at the air-liquid interface shows significant increase in publications.

Inhalation toxicity of thermal transformation products formed from e-cigarette vehicle liquid using an in vitro lung model exposed at the Air–Liquid Interface

Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model

Impact of Electronic Cigarettes, Heated Tobacco Products and Conventional Cigarettes on the Generation of Oxidative Stress and Genetic and Epigenetic Lesions in Human Bronchial Epithelial BEAS-2B Cells

In vitro micronucleus in V79 cells using MicroFlow® – Treatment at the air liquid interface with aerosol from three different nicotine containing products

In vitro cytotoxicity and mechanistic insight from MucilAir™ and SmallAir™ tissues exposed to cigarette smoke and next-generation products

Validation of the Vitrocell® HTP 2.0+ 12-well mammalian module for assessing cigarettes, ENDS and eHTPs: Evaluation of dilution airflow, dose resolution and dose repeatability

A multi-organ, lung-derived inflammatory response following in vitro airway exposure to cigarette smoke and next-generation nicotine delivery products

VITROCELL at the CORESTA Conference of the Smoke Science and Product Technology Sub-Groups (SSPT2023), 08-12 October 2023

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