LIVe 2024 , 20-21. June, Nice, France
Aline Chary1, Charlotte Stoffels1, Carla Ribalta Carrasco3, Dirk Brossell2, Rob Vandebriel3, Tommaso Serchi1
1 LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST), Esch Sur Alzette, Luxembourg; aline.chary@list.lu
2 BUNDESANSTALT FUER ARBEITSSCHUTZ UND ARBEITSMEDIZIN (BauA), Berlin, Germany
3 RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (RIVM), Bilthoven, Netherlands
BACKGROUND
The MACRAMÉ project (for Advanced Characterisation Methodologies to assess and predict the Health and Environmental Risks) is dedicated to creating a structured approach for studying in vitro inhalation toxicology through a series of in vitro and ex vivo models that mimic the biological complexity of the human respiratory system, including both the upper and lower airways. This project will conduct rigorous testing, validation, and implementation of various biological models that reflect the human respiratory system, focusing on the bronchial region (upper airways) and the alveolar region (lower airways). Currently, there exists a noticeable data gap concerning the suitability of these models for nanomaterials and advanced materials. MACRAMÉ seeks to validate the efficacy of these proposed methodologies in assessing such inhalable pollutants. In this context, it is essential to assess various exposure devices to establish a decision tree for selecting the most suitable device and biological system depending on the nature of the material and biological endpoint of interest.
