EUROTOX 08.-11.September 2024, Copenhagen, Denmark
Samuel Buxton1, Maria Kloukinioti2, Mariska Grollers-Mulderij2, Evert Duistermaat3, Peter Tromp2, Frederique van Acker3, Adriana Oller4, Ingeborg M Kooter2
1NiPERA Inc., 2525 Meridian Pkwy Ste 240 Durham NC 27713 USA
2The Netherlands Organization for Applied Scientific Research, TNO, Utrecht, The Netherlands
3Triskelion BV, Zeist, The Netherlands
4Oller Consulting LLC, Durham NC 27703
Introduction
Ni is used in many applications, from stainless steel to batteries. Historically, Ni ore refining has been associated with increase in lung and nasal cancers[2].
Robust databases of human and animal data are available for Ni and Ni compounds to support refined risk assessments[2,3]. However, uncertainties exist about the comparability of toxicity between soluble and insoluble Ni compounds, and between animals and humans.
3D respiratory cell models with ALI exposures reduce animal use, are more realistic in vitro test systems that mimic in vivo inhalation, and allow the correlation of responses in animals to human tissues, potentially bridging any toxicity gap.
This pilot study using two Ni compounds in rat and human MucilAir models was conducted to address the rat-to-human toxicity comparability gap and investigate the differential sensitivity to toxicity triggered by the two Ni compounds.
