96-well Air/Liquid Interface (ALI) exposure. For reliable high throughput testing of cell cultures.
The VITROCELL® Cloud Alpha 96 is our innovation and presents a great leap forward in automated exposure of cell cultures at the Air/Liquid Interface (ALI). It combines high throughput testing with ease of use. The development is based on the well-known and frequently published VITROCELL® Cloud formats (6-, 12- and 24-well). It’s functionality enables fully automated processes with an all-in-one control unit. Everyday experiments at the air/liquid interface have never been easier.
The new Cloud Alpha 96 series was developed as a result of numerous customer requests and is now capable to expose mammalian cell cultures in 96-well Permeable Support Systems.
The Cloud system is suitable for nebulization of solutions and suspensions. Possible fields of application are screening of inhaled drugs, toxicity testing of inhaled substances such as chemicals or nanoparticles and virus research.
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In response to the scientific need to expose in physiologically relevant conditions, the VITROCELL® Cloud Alpha exposure devices have been specifically designed to enable direct exposure of mammalian cells or tissue at the Air/Liquid Interface. Here the cell cultures are not covered with media as opposed to submerged conditions which cause an undesired interaction of the formerly airborne substances with the culture media.
Cell systems cultivated on membrane inserts are exposed at the Air/Liquid Interface (ALI) so that the test substances are received directly. This approach allows for more credible and authentic results than by submerged exposure due to a closer replication of the human physiology.
A: Direct and controlled exposure of test atmosphere to cells
B: Cells on membrane
C: Media below cells
The system offers a selection of three types of vibrating mesh nebulizers, with droplet MMAD ranges of 4.0 – 6.0 µm, 4.0 – 6.0 µm, 2.5 – 6.0 µm, and 4.0–6.0 µm, 12 µm, 17 µm, and 20 µm.
With a recommended nebulization volume of 200 µL for the Cloud Alpha 96, the device is especially well-suited for experiments where only small amounts of test material are available.
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