VITROCELL^® CalorQuanti

Innovative optical dosimetry tool for real-time deposition monitoring

The latest innovation of online dosimetry assessment was developed in a joint project of NanoLockin and VITROCELL^®.

The new CalorQuanti can be used to optically analyze the particle dose in VITROCELL^® Cloud Alpha Systems or as standalone unit. It uses an innovative lock-in thermography system, which allows to measure the heating of particles upon light irradiation. The amount of heat produced can be correlated to the deposited dose.

More about VITROCELL CalorQuanti

Function Principle

Laser pulses light on ALI
Particles and cells emit different IR-radiation
Lock-in thermography allows for analysis of temperature differences in the mK range
The measured heat can be correlated to the particle concentration

IR-radiation can be correlated to particle concentration. Combustion particles deposited on lung cells were detected by lock-in thermography (upper figure) and visualized by transmission electron microscopy (lower figure). The thermal signal intensity was homogeneous at both concentrations and increased with particle levels.

Features

Allows for non-invasive, real-time dosimetry
Particle deposition is measured on living cells, directly at the air-liquid interface
Does not sacrify a cell culture position in the exposure system
Capable of analyzing particle types with darker color: combustion particles (e.g., diesel and aircraft emissions), tire wear particles, metal particles, break wear particles, carbon particles (graphene, carbon black and nanotubes)
Also available as standalone version

Downloads

Leaflet VITROCELL CalorQuanti

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